Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis

Abidi, S.S.A. and Azim, Y. and Khan, S.N and Khan, A.U. (2018) Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis. Journal of Pharmaceutical and Biomedical Analysis, 149. pp. 351-357. ISSN 7317085

Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...

Abstract

Sulfaguanidine (SG), belongs to the class of sulfonamide drug used as an effective antibiotic. In the present work, using crystal engineering approach two novel cocrystals of SG were synthesized (SG-TBA and SG-PT) with thiobarbutaric acid (TBA) and 1,10-phenanthroline (PT), characterized by solid state techniques viz., powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and the crystal structures were determined by single crystal X-ray diffraction studies. A comparative antibacterial activity and hemolytic potential was done on SG drug, coformers and their cocrystals. The tested cocrystals formulations showed almost two fold higher antibacterial activity against the tested strains of bacteria Gram-positive bacteria (S. mutans and E. faecalis) and Gram-negative bacteria (E. coli, K. pneumonia and E. clocae) over SG alone and their coformers. Cocrystal SG-TBA showed better antibacterial activity and reduced hemolysis, thereby, reduced cytotoxicity than SG-PT. © 2017 Elsevier B.V.

Item Type: Article
Uncontrolled Keywords: Antibacterial; Cocrystals; Hemolytic potential; Sulfaguanidine
Subjects: T Technology > T Technology (General)
Divisions: Faculties > Faculty of Engineering and Technology > Zakir Husain College of Engineering & Technology > Department of Applied Chemistry
Depositing User: AMU Library
Date Deposited: 18 Jan 2018 10:33
Last Modified: 18 Jan 2018 10:33
URI: http://ir.amu.ac.in/id/eprint/10795

Actions (login required)

View Item View Item