Hyperglycemia induced reactive species trigger structural changes in human serum albumin of type 1 diabetic subjects

Arif, Z. and Neelofar, K. and Arfat, M.Y. and Zaman, A and Tarannum, A. and Parveen, I. and Ahmad, S. and Khan, M.A., and Badar, A and Islam, S.N. (2018) Hyperglycemia induced reactive species trigger structural changes in human serum albumin of type 1 diabetic subjects. International Journal of Biological Macromolecules, 107. pp. 2141-2149. ISSN 1418130

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Abstract

Chronic oxidative stress fuels pathogenesis of a large set of diseases. Oxidative stress is the cause and consequence of numerous diseases including type 1 diabetes mellitus (T1DM), in which there is selective destruction of insulin producing pancreatic β-cells. Studies have documented that hyperglycemia produces profound stress. In vivo production of numerous reactive oxygen, nitrogen, chlorine species and lipid/sugar oxidation products in T1DM patients may be the result of persistent hyperglycemia. Post-translational modifications by reactive species may create new antigenic epitopes and play a role in the development of autoimmune response. In this paper our main focus was to establish the effect of existing hyperglycemia induced oxido-nitrosative stress in T1DM patients on the integrity of human serum albumin. Raised nitric oxide, carbonyl, RBC hemolysis, lowered ferric reducing antioxidant power (FRAP), thiol and deformed RBC in T1DM are all highly suggestive of persistent oxido-nitrosative stress. Hyperglycemia induced generation of advanced glycation end products (AGEs) was established by LCMS. Chronic oxido-nitrosative stress can modify HSA in T1DM patients, producing immunologically active albumin. Therefore, it is speculated that the aberrant HSA may play a role in the initiation/progression of T1DM.

Item Type: Article
Uncontrolled Keywords: Glycation; Human serum albumin; Hyperglycemia; Type1 diabetes mellitus
Divisions: Faculties > Faculty of Life Sciences > Department of Biochemistry
Depositing User: AMU Library
Date Deposited: 19 Jan 2018 05:29
Last Modified: 19 Jan 2018 05:29
URI: http://ir.amu.ac.in/id/eprint/10829

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