An overview of in vitro and in vivo glycation of albumin: a potential disease marker in diabetes mellitus

Neelofar, K. and Ahmad, J. (2017) An overview of in vitro and in vivo glycation of albumin: a potential disease marker in diabetes mellitus. Glycoconjugate Journal, 34 (5). pp. 575-584. ISSN 2820080

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Non-enzymatic glycation of macromolecules, especially proteins leading to their oxidation is increased in diabetes mellitus due to hyperglycaemia and play an important role in associated complications of the disease. Protein glycation mostly occurs in intra chain lysine residues resulting in the formation of early stage Amadori products which are finally converted to advance glycation end products (AGEs). This review deals with the structural studies of in vitro and in vivo glycated human serum albumin (HSA). The aim of this review is to explain the disturbance in secondary and tertiary structure of albumin upon glucosylation and the immunogenic potential of modified albumin. Amadori-albumin may have enough potential to provoke the immunoregulatry cells and generate autoantibodies in diabetic patients. Role of Amadori-albumin in the induction of autoantibodies in type2 diabetes especially in chronic kidney disease (CKD) patients has been discussed. This review also considers various studies that investigate the effects of glycation on the structural and immunological properties of HSA. The use of glycated albumin (GA) as a short to intermediate term marker for glycaemic control in diabetes is also focused.

Item Type: Article
Uncontrolled Keywords: Diabetes; Diagnostic marker; Glycated albumin; Human serum albumin; Protein modification
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Faculty of Medicine
Depositing User: AMU Library
Date Deposited: 22 Jan 2018 10:54
Last Modified: 22 Jan 2018 10:54

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