Effects of d-α-tocopherol on skeletal muscle regeneration in crushed injury of diabetic rats

Elsy, B. and Khan, A.A. and Maheshwari, V. (2017) Effects of d-α-tocopherol on skeletal muscle regeneration in crushed injury of diabetic rats. European Journal of Anatomy, 21 (4). pp. 293-304. ISSN 11364890

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Abstract

Muscular atrophy in diabetes is believed to be due to uncontrolled hyperglycemia and oxidative stress. Vitamin E, a natural antioxidant, is consid-ered important to maintain skeletal muscle struc-tures and functions. The current study is designed to explore the regenerative potential of d-α-tocopherol after crushed injury of skeletal muscle in healthy and diabetic rats. Diabetes was induced through single subcutaneous injection of alloxan at the dose of 100 mg/kg at hip region. Twenty four albino rats were divided into four groups; healthy control, diabetic control, healthy treated and dia-betic treated. Treated groups were administered d-α-tocopherol orally and daily at the dose of 200 mg/kg for three weeks. A horizontal skin incision was made on the shaved right mid-thigh region and after splitting of the fascia between gluteus maximus and tensor fascia lata the gluteus maxi-mus was crushed with Kocher's forceps. Skin wound was closed with an absorbable suture. The crushed muscle changes were studied by as-sessing the histopathological features, histomor-phological measurements and biochemical anal-yses at the end of 3rd week. One way 'ANOVA' followed by Tukeys test and Student t test were used for statistical analysis. Results obtained through various methods indicate that the d-α-tocopherol helps in skeletal muscle regeneration by improving antioxidant status, myoblast prolifera-tion, revascularization, reinnervation and connec- tive tissue remodeling. Hence it is concluded that d-α-tocopherol is a useful therapeutic dietary sup-plement in the management of skeletal muscle crushed injuries in both healthy and diabetics.

Item Type: Article
Uncontrolled Keywords: Antioxidant; Crush-injury; D-α-tocopherol; Diabetes; Muscle; Rats
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Faculty of Medicine > J.N. Medical College > Department of Anatomy
Depositing User: AMU Library
Date Deposited: 22 Jan 2018 10:56
Last Modified: 22 Jan 2018 10:56
URI: http://ir.amu.ac.in/id/eprint/10901

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