Dutasteride in androgenetic alopecia: An update

Arif, T. and Dorjay, K. and Adil, M. and Sami, M. (2017) Dutasteride in androgenetic alopecia: An update. Current Clinical Pharmacology, 12 (1). pp. 31-35. ISSN 15748847

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Abstract

Background: Androgenetic alopecia is a common condition characterized by thinning of scalp hair. Conversion of testosterone to dihydrotestosterone, a more potent androgen, by the enzyme 5-α-reductase is responsible for underlying pathogenesis. Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type-1 and type-2 isoenzymes of 5-α-reductase. Finasteride and minoxidil are the only approved drugs for androgenetic alopecia. Dutasteride has been demonstrated to be effective in several randomized, double-blind, placebo controlled trials in androgenetic alopecia. In this review, after the pharmacology of dutasteride, the authors have discussed the status of dutasteride in androgenetic alopecia and have compared its efficacy with that of finasteride. Objective: This article aims to review the current status of dutasteride in androgenetic alopecia. The structure, mechanism of action, pharmacokinetics and side effects are discussed along with its comparison with finasteride in androgenetic alopecia. Method: The main sources of our information were Medline Pubmed, Google scholar and Scopus including original articles and review articles. The keywords 'dutasteride', 'dutasteride in androgenetic alopecia' were used for search. Conclusion: Like finasteride, dutasteride is now becoming popular treatment option in AGA, due to its good response shown by various randomized control studies and meta-analysis. Also, in most of these studies, dutasteride was found to be better than finasteride with comparable adverse effects. Therefore, dutasteride could become a treatment of choice for AGA in near future.

Item Type: Article
Uncontrolled Keywords: 5-α-reductase; Androgenetic alopecia; Dihydrotestosterone; Dutasteride; Finasteride; Minoxidil; Testosterone
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Faculty of Medicine > J.N. Medical College > Department of Dermatology
Depositing User: AMU Library
Date Deposited: 25 Jan 2018 11:17
Last Modified: 25 Jan 2018 11:17
URI: http://ir.amu.ac.in/id/eprint/10989

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