Comparative efficacy of epigallocatechin-3-gallate against H2O2-induced ROS in cervical cancer biopsies and HeLa cell lines

Hussain, S. (2017) Comparative efficacy of epigallocatechin-3-gallate against H2O2-induced ROS in cervical cancer biopsies and HeLa cell lines. Wspolczesna Onkologia, 21 (3). pp. 209-212. ISSN 14282526

Full text not available from this repository.
Official URL: https://www.termedia.pl/Comparative-efficacy-of-ep...

Abstract

Aim of the study: Antioxidants play an important role in maintaining physiological homeostasis. Recent literature emphasises the potential therapeutic effects of natural antioxidants that play anti-inflammatory and antioxidant effects applicable in preventing oxidative stress-induced injury, which characterises their pathogenesis. The goal of this study was to evaluate the protective role of EGCG on the HeLa cell line and cancerous cells. Material and methods: The HeLa cell line and cervical cancer biopsies (CCB) were treated with varying doses of antioxidants to determine their effects. Thereafter, hydrogen peroxide (0-10 nM) - an ROS-generating compound - was co-cultured with varying doses of epigallocatechin-3-gallate (EGCG). The effect of this compound on superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was assessed. Result: The activity of SOD and GPx was protected significantly in the treatment of EGCG in cervical cancer biopsies and HeLa cell line. Hypothesis: It is hypothesised that EGCG has free radical scavenging properties. Conclusions: EGCG protected the activity SOD and GPx equally in cervical cancer biopsies (CCB) and HeLa cell line.

Item Type: Article
Uncontrolled Keywords: Cervical Cancer; EGCG; GPx; HeLa; SOD
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Faculty of Life Sciences > Department of Biochemistry
Depositing User: AMU Library
Date Deposited: 29 Jan 2018 06:38
Last Modified: 01 Feb 2018 05:29
URI: http://ir.amu.ac.in/id/eprint/11000

Actions (login required)

View Item View Item