Multiple biomarker responses (serum biochemistry, oxidative stress, genotoxicity and histopathology) in Channa punctatus exposed to heavy metal loaded waste water /704/172/4081 /631/601 article

Javed, M. and Ahmad, M.I. and Usmani, N. and Ahmad, M. (2017) Multiple biomarker responses (serum biochemistry, oxidative stress, genotoxicity and histopathology) in Channa punctatus exposed to heavy metal loaded waste water /704/172/4081 /631/601 article. Scientific Reports, 7 (1). ISSN 20452322

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Official URL: http://www.worldscientific.com/doi/abs/10.1142/S17...

Abstract

Experiments were conducted to investigate the health of fish Channa punctatus inhabiting heavy metal-loaded waste water. Heavy metals in the order of Fe > Mn > Zn > Co > Ni > Cu = Cr were present in the waste water. Gills had high metal load followed by liver and then kidney. Albumin, albumin to globulin (A:G) ratio, triglyceride, high density lipoprotein (HDL) and very low density lipoprotein (VLDL) were found to be lower but phospholipid, low density lipoprotein (LDL), total protein, lipid and cholesterol were higher as compared to the reference. Oxidative stress markers such as superoxide dismutase (SOD), catalase (CAT), glutathione S transferase (GST) and lipid peroxidation (LPO) were significantly higher in all tissues, whereas reduced glutathione (GSH) levels were comparatively low. Damage to DNA was observed with significantly higher mean tail length of comets in the exposed fish gill cells (30.9 μm) followed by liver (24.3 μm) and kidney (20.6 μm) as compared to reference fish (5.2, 4.8 and 5.9 μm respectively). Histopathology in gill, liver and kidney also showed marked damage. Integrated biochemical, oxidative stress, genotoxicity and histopathological findings are valuable biomarkers for native fish adaptive patterns, and monitoring of water quality/pollution of freshwater ecosystems.

Item Type: Article
Subjects: Q Science > QL Zoology
Divisions: Faculties > Faculty of Life Sciences > Department of Zoology
Depositing User: AMU Library
Date Deposited: 30 Jan 2018 06:08
Last Modified: 31 Jan 2018 07:15
URI: http://ir.amu.ac.in/id/eprint/11035

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