Effect of Myricetin on the Oxidative Stress Markers in the Brain of Transgenic Flies Expressing Human Alpha-Synuclein

Ara, G. and Afzal, M. and Jyoti, S. and Siddique, Y.H. (2017) Effect of Myricetin on the Oxidative Stress Markers in the Brain of Transgenic Flies Expressing Human Alpha-Synuclein. International Journal of Nutrition, Pharmacology, Neurological Diseases, 7 (4). pp. 101-106. ISSN 22310738

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Official URL: http://www.ijnpnd.com/article.asp?issn=2231-0738;y...

Abstract

Background: Parkinson's disease (PD) is a neurodegenerative disorder having no permanent cure, but there has been a great deal of interest in finding the role of complementary and alternative medicines for the treatment of neurodegenerative disorders. Oxidative stress has also been implicated in the progression of PD. Objective: Since ancient time, natural plant products have been studied for their protective action. In this study, the effect of myricetin was studied on transgenic flies expressing human alpha-synuclein in the neurons. Materials and Methods: The PD flies were allowed to feed on a diet supplemented with 5, 10, and 20 μM of myricetin for 24 days. The flies with PD were then subjected to the study of oxidative stress markers. Results: The results of this study reveal that the exposure of flies with PD to myricetin showed a significant dose-dependent decrease in oxidative stress compared to unexposed flies with PD (P < 0.005). Conclusion: Myricetin is potent in reducing oxidative stress in the brain of flies with PD induced by the expression of human alpha-synuclein and the formation of Lewy bodies.

Item Type: Article
Uncontrolled Keywords: Alpha-synuclein; myricetin; Parkinson's disease
Subjects: Q Science > QL Zoology
Divisions: Faculties > Faculty of Life Sciences > Department of Zoology
Depositing User: AMU Library
Date Deposited: 06 Feb 2018 04:29
Last Modified: 06 Feb 2018 04:49
URI: http://ir.amu.ac.in/id/eprint/11121

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