Taurine mitigates nitrite-induced methemoglobin formation and oxidative damage in human erythrocytes

Ansari, F.A. and Ali, S.N. and Mahmood, R. (2017) Taurine mitigates nitrite-induced methemoglobin formation and oxidative damage in human erythrocytes. Environmental Science and Pollution Research, 24 (23). pp. 19086-19097. ISSN 9441344

Full text not available from this repository.
Official URL: https://link.springer.com/article/10.1007%2Fs11356...

Abstract

Nitrite is present as a noxious contaminant in drinking water and causes oxidative damage in various tissues of humans and animals. It is a well-known methemoglobin-forming agent that has been shown to damage blood cells. The protective effect of taurine, a semi-essential sulfur-containing amino acid, was studied on sodium nitrite (NaNO2)-induced oxidative damage in human erythrocytes. Erythrocytes were incubated with NaNO2, in the presence and absence of taurine, and changes in oxidative stress parameters determined. Pretreatment with taurine significantly ameliorated NaNO2-induced oxidative damage to lipids, proteins, and plasma membrane. It also reduced the NaNO2-induced increase in methemoglobin levels and ROS production. Taurine improved the antioxidant capacity of cells, restored the alterations in the activities of various metabolic enzymes, and prevented morphological changes in erythrocytes. Thus, taurine can be potentially used as a protective agent against the damaging effects of nitrite. © 2017, Springer-Verlag GmbH Germany.

Item Type: Article
Divisions: Faculties > Faculty of Life Sciences > Department of Biochemistry
Depositing User: AMU Library
Date Deposited: 07 Feb 2018 05:44
Last Modified: 07 Feb 2018 06:03
URI: http://ir.amu.ac.in/id/eprint/11171

Actions (login required)

View Item View Item