Glycated albumin and the risk of chronic kidney disease in subjects with Type 2 Diabetes: A study in North Indian Population

Raghav, A. and Ahmad, J. and Noor, S. and Alam, K. and Mishra, B.K. (2018) Glycated albumin and the risk of chronic kidney disease in subjects with Type 2 Diabetes: A study in North Indian Population. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. ISSN 18714021 (In Press)

Full text not available from this repository.
Official URL: https://www.sciencedirect.com/science/article/abs/...

Abstract

Aim: Glycated albumin (GA) suggested being alternative glycemic marker than haemoglobin A1C (HbA1c) in patients with chronic kidney diseases (CKD). We investigated the association between GA and the progression of diabetic nephropathy (DN) in T2DM subjects. Methods: We recruited T2DM subjects with different stages of CKD who had regularly measured serum creatinine and estimated glomerular filtration rates (eGFR) according to Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines, HbA1c consecutively every 3 months along with GA levels and other anthropometric and demographic measurements. We grouped age and sex matched subjects into the CKD progression, Group I healthy subjects (n = 100, M: F;50:50). Group II T2DM subjects with eGFR ≥90 mL/min (n = 167, M:F; 76:91). Group III of T2DM patients with eGFR 60-89 mL/min (n = 91, M:F; 44:47). Group IV T2DM subjects with eGFR 30-59 mL/min (n = 68, M:F;31:37). Group V T2DM with eGFR ≤ 29 mL/min (n = 21, M:F; 13:8). Results: Pearson's correlation analysis between glycated albumin and biochemical parameters were established in all subjects. GA/HbA1c ratio increases with poor glycemic control except for nephrosis state. Conclusion: Mean GA levels were more closely associated with DN progression than mean HbA1c in subjects with T2DM and can be implemented as an alternative diagnostic marker in nephropathy.

Item Type: Article
Uncontrolled Keywords: Diabetic nephropathy; Glycated albumin; Type 2 diabetes mellitus
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculties > Faculty of Medicine > J.N. Medical College
Depositing User: AMU Library
Date Deposited: 22 Mar 2018 11:32
Last Modified: 22 Mar 2018 11:32
URI: http://ir.amu.ac.in/id/eprint/11276

Actions (login required)

View Item View Item