Diabetes and Metabolic Syndrome: Clinical Research and Reviews

Raghav, A. and Ahmad, J. (2018) Diabetes and Metabolic Syndrome: Clinical Research and Reviews. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. ISSN 18714021 (In Press)

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Abstract

Nephropathy in diabetes patients is the most common etiology of end-stage kidney disease (ESKD). Strict glycemic control reduces the development and progression of diabetes-related complications, and there is evidence that improved metabolic control improves outcomes in subjects having diabetes mellitus with advanced chronic kidney disease (CKD). Glycemic control in people with kidney disease is complex. Changes in glucose and insulin homoeostasis may occur as a consequence of loss of kidney function and dialysis. The reliability of measures of long-term glycemic control is affected by CKD and the accuracy of glycated haemoglobin (HbA1c) in the setting of CKD and ESKD is questioned. Despite the altered character of diabetes in CKD, current guidelines for diabetes management are not specifically adjusted for this patient group. The validity of indicators of long-term glycemic control has been the focus of increased recent research. This review discusses the current understanding of commonly used indicators of metabolic control (HbA1c, fructosamine, glycated albumin) in the setting of advanced CKD.

Item Type: Article
Uncontrolled Keywords: Chronic kidney disease; Fructosamine; Glycated albumin; Glycated haemoglobin; Glycemic control
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculties > Faculty of Medicine > J.N. Medical College
Depositing User: AMU Library
Date Deposited: 22 Mar 2018 11:48
Last Modified: 22 Mar 2018 11:48
URI: http://ir.amu.ac.in/id/eprint/11277

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