Perillyl alcohol alleviates amyloid-β peptides-induced mitochondrial dysfunction and cytotoxicity in SH-SY5Y cells

Zafeer, M.F. and Firdaus, F. and Ahmad, F. and Ullah, R. and Anis, E. and Waseem, M. and Ali, A. and Hossain, M.M. (2018) Perillyl alcohol alleviates amyloid-β peptides-induced mitochondrial dysfunction and cytotoxicity in SH-SY5Y cells. International Journal of Biological Macromolecules, 109. pp. 1029-1038. ISSN 01418130

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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common type of dementia in elderly (>65 years of age). Excessive extra cellular deposits of amyloid beta (Aβ) are a pathological feature of AD. Aβ can cause cell death through oxidative damage; recent studies have implicated opening of mPTP as a detrimental event in AD-related mitochondrial dysfunctions. Over the past few years, natural compounds with antioxidant properties have shown promise for intervention in AD.

Item Type: Article
Subjects: Q Science > QL Zoology
R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Divisions: Centres > Interdisciplinary Brain Research Center
Centres > Interdisciplinary Brain Research Center
Depositing User: AMU Library
Date Deposited: 24 Mar 2018 04:59
Last Modified: 24 Mar 2018 04:59
URI: http://ir.amu.ac.in/id/eprint/11280

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