Enhancing the production of anticancer alkaloids and physiological activities of periwinkle (Catharanthus roseus L.) using radiolytically degraded natural polysaccharides and methyl jasmonate (MJ)

Moinuddin, . (2015) Enhancing the production of anticancer alkaloids and physiological activities of periwinkle (Catharanthus roseus L.) using radiolytically degraded natural polysaccharides and methyl jasmonate (MJ). .. (Unpublished)

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Abstract

The Project aimed at enhancing the total as well as anticancer alkaloids of Catharanthus roseus. Six pot experiments, conducted in the net house, revealed that single application of the irradiated natural polysaccharides (sodium alginate and chitosan) could improve the growth, physiological attributes, herbage yield and the content and yield of total alkaloids in Catharanthus roseus. Though it increased the yield (because of increase in herbage/leaf yield), but could not significantly increase the content of anticancer alkaloids (vincristine and vinblastine) in the leaf. However, application of either of ϒ-irradiated sodium alginate (ISA) or ϒ-irradiated chitosan (IC) along with methyl jasmonate (MeJA) significantly increased the content as well as yield of the anticancer alkaloids. The combination of ISA, IC and MeJA gave the best results. Thus, the protocol generated, can highly benefit the community as it enhanced production of the alkaloids used in cancer chemotherapy; this research is important because the cost of these anticancer alkaloids is very high due to their very low content in the leaves of Catharanthus roseus, which is the only source of their production.

Item Type: Other
Subjects: Q Science > QK Botany
Divisions: Faculties > Faculty of Life Sciences > Department of Botany
Depositing User: AMU Library
Date Deposited: 05 Apr 2018 04:26
Last Modified: 05 Apr 2018 04:26
URI: http://ir.amu.ac.in/id/eprint/11307

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