Role of Carbamylated Biomolecules in Human Diseases

Badar, A. and Arif, Z. and Alam, K. (2018) Role of Carbamylated Biomolecules in Human Diseases. IUBMB Life, 70 (4). pp. 267-275. ISSN 15216543

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Carbamylation (or carbamoylation) is a non-enzymatic modification of biomolecules mediated by cyanate, a dissociation product of urea. Proteins are more sensitive to carbamylation. Two major sites of carbamylation reaction are: Nα-amino moiety of a protein N-terminus and the Nɛ-amino moiety of proteins’ lysine residues. In kidney diseases, urea accumulates and the burden of carbamylation increases. This may lead to alteration in the structure and function of many important proteins relevant in maintenance of homeostasis. Carbamylated proteins namely, carbamylated-haemoglobin and carbamylated-low density lipoprotein (LDL) have been implicated in hypoxia and atherosclerosis, respectively. Furthermore, carbamylation of insulin, oxytocin, and erythropoietin have caused changes in the action of these hormones vis-à-vis the metabolic pathways they control. In this short review, authors have compiled the data on role of carbamylated proteins, enzymes, hormones, LDL, and so on, in human diseases.

Item Type: Article
Uncontrolled Keywords: Biomolecules; Carbamylation; Cyanate; Diseases
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculties > Faculty of Medicine > J.N. Medical College > Department of Biochemistry

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